angela kedgley - darshan shah

Human Biomechanics Research for Better Health Solutions

The Kedgley Biomechanics Lab is working to build our understanding of the mechanics of human upper limb in an effort to provide more efficient and effective methods of diagnosis and treatment for patients.

Research Overview

The Kedgley Biomechanics Lab employs a variety of in-vivo and in-vitro approaches to examine the effects of ageing and joint pathologies in the upper limb. These techniques include both experimental and computational methods, employing optical motion analysis, imaging, and experimental testing. We aim to work with clinicians to aid in the assessment of therapeutic interventions and the development of new techniques to promote early diagnosis of joint pathologies, leading to preventative rather than reactive treatment strategies.

Reverse Engineering Osteoarthritis

Hand osteoarthritis affects more than 8% of the population over the age of 60 and currently has no cure. Symptoms include pain and swelling of the joints, resulting in significant deformity, leading to stiffness, and prohibiting a sufferer from performing everyday tasks. Unfortunately, our understanding of hand osteoarthritis dramatically lags behind that of larger joints, such as the hip and knee, because the complexity of the hand makes it difficult to study.

Select Publications

  1. Shah DS, Middleton C, Gurdezi S, Horwitz MD, Kedgley AE. (2017) The effects of wrist motion and hand orientation on muscle forces: a physiologic wrist simulator study, Journal of Biomechanics (In press).
  2. Shah DS, Kedgley AE. (2016) Control of a wrist joint motion simulator: a phantom study, Journal of Biomechanics 49(13): 3061–3068. doi:10.1016/j.jbiomech.2016.07.001
  3. Amabile C, Bull AM, Kedgley AE. (2016) The centre of rotation of the shoulder complex and the effect of normalisation, Journal of Biomechanics 49(9): 1938-1943. doi:10.1016/j.jbiomech.2016.03.035
  4. Kedgley AE, Dunning CE. (2010) An alternative definition of the scapular coordinate system for use with RSA, Journal of Biomechanics 43(8): 1527-1531.
  5. Kedgley AE, Jenkyn TR. (2009) RSA calibration accuracy of a fluoroscopy-based system using nonorthogonal images for measuring functional kinematics, Medical Physics 36(7): 3176-3180.
  6. Kedgley AE, Birmingham T, Jenkyn TR. (2009) Comparative accuracy of radiostereometric and optical tracking systems, Journal of Biomechanics 42(9): 1350-1354.